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KMID : 0361020140570040207
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Korean Journal of Otolaryngology - Head and Neck Surgery
2014 Volume.57 No. 4 p.207 ~ p.213
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Application of Mesenchymal Stem Cells in Rhinologic Fields
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Cho Kyu-Sup
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Abstract
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Mesenchymal stem cells (MSCs) are adult stem cells which are present in a variety of adult tissues and reside in essentially all post-natal organs and tissues. MSCs represent an important stem cell population with multi-potent capabilities which may have high utility for translational clinical applications. MSCs can be isolated from a number of adult tissues and differentiate into several mesenchymal lineages both in vitro and in vivo, such as bone, cartilage, adipose tissue, and muscle. Because of their capacities of differentiation, MSCs have emerged as a promising source for therapeutic applications in tissue engineering and regenerative medicine. In addition to their multi-lineage potential, MSCs have been shown to possess the unique ability to suppress immune response and modulate inflammation. MSCs can inhibit natural killer cell function, modulate dendritic cell maturation, and suppress the allogeneic T-cell response by alternating the cytokine secretion profile of dendritic cells and T-cells induced by an allogeneic immune reaction. Therefore, MSCs have been reported to have anti-inflammatory and immunomodulatory effects in a variety of chronic inflammatory diseases. In this article, I review recent experimental data and discuss about the application of MSCs in rhinologic fields.
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KEYWORD
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Allergic rhinitis, Asthma, Immunosuppression, Mesechymal stem cells, Nasal polyps, Nerve regeneration, Olfaction disorders, Respiratory mucosa
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